collected from the Dermatology. Department Benha University Hospitals and from the files of Pathology
Department, Zagazig University . All cases were of the classical type and non of them was AIDSassociated
. The cases included early lesions , patches and plaques (4casfes) and nodular lesions (8 cases)
.All specimens were performed using FV111 RA , CD34 ( QBEnd/10)ndTaminin . The staining and
image analysis were done in the Early Cancer Detection Unit Zagazig University . The endothelial cell
lining vascular spaces stained by FV111 RA with variable staining intensity in all cases . CD34
immunoreactivity was observed in endothelial cells lining vascular spaces in 10 out of 12 cases (83.3%)
with variable but weaker staining intensity while laminin immunoreactivity was obsserved in only 7 out of
12 cases (58.3%) , with mild and patchy positive reaction . The spindle cell component revealed mild
patchy positive reaction for FV111 RA ( 8 out of 12 cases , 66.7% ) , more distinct positive reaction for
CD34 ( 11 out of 12 cases , 91.67% ) and laminin ( 9 out of 12 cases, 75% ) with variable staining
intensity.DNA image analysis was done in all cases and the results were correlated with clinical and
immunohistochemical findings. The study concluded that Kaposi's sarcoma is a tumor of endothelial origin
with strongly suggested derivation of spindle cell elements in both early and late nodular lesions from
lymphatic endothelium, rather than blood vascular endothelium |
