Tissue fromnon-infected eruption offifty AD
subjects, non-lesional skin of10patients and
from normal skin of 10 healthy persons was
subjected to direct immunofluorescence tech
nique using fiuorescein isothiocyanate la
belled antiserumspecific for IgE and indirect
immunofluorescence technique using mono
clonal antibodies, IgE was detected in the lesional
skin of 88%ofcases in both epidermis
and dermis. T-helper cells were present in all
biopsiesfromlesional skin while T-suppressor
cells were present in fewer num-ber of
biopsies. Langerhans cells (LCs) were found
in all biopsies from lesional skin of AD
patients.
This study suggests that IgE mediated type IV
hypersensitivity may be implicated in the ae
tiology ofatopic dermatitis |
