The aim of intralesional steroid injection is to attain high
concentration ofsteroids at the diseased site in the skin. Intralesional
steroid injection is usedmainly for localized chronic lesionswhich
do not respond to topical steroids and/or wherever prolonged
systemic steroid therapy is undesirable.
In this study the adrenal functions was studied following
intralesional injection ofdiluted triamcinolone acetonide (10mg/ml)
in doses of0.5ml inmanaging 10 caseswith patchy alopecia areata,
lml inmanaging 10 cases with localized chronic eczema, and 2ml in
managing 10 caseswith localized plaquepsoriasis.
AH patients in this study had complete history taking, general
and local examination at the first visit and also at the followup
visits. Intalesional injection ofdiluted triamcinolone acetonidewas
done using insulin syringe with a gauge of27-30 at the firstvisit,
after 3weeks and 6 weeks.
The hypothalamic pituitary-adrenal axis function was
investigated by using longACTHstimulation test (long synacethen
test) at 3 weeks and 6 weeks following intralesional injection of
diluted triamcinolone acetonide by taking blood samples fromevery
patient after intramuscular injection of p1"24 corticotrophin
(tetracosatide hexacetate) adsorbed to zinc phosphate which is
SUMMARYAND CONCLUSIONI
ISUMMARYAND CONCLUSION^
available as Synathen depot, at 0, 1 hour, 4 hours, 8 hpurs^nd 24
hours both at 3 and 6 weeks for measuring serum cortisol level
which is done using immulite cortisol kits.
In the present study there was no statistically significant
suppression ofthe hypothalamicpituitary-adrenal axis in all patients
both at 3 and 6 weeks following intralesional injection ofdiluted
triamcinolone acetonide with a maximum dose of 2 ml (eachml
containing lOmg oftriamcinolone acetonide) andminimumdose of
0.5ml. |
