Fourty patients were randomly allocated. into 2 groups: Group I anaesthesia was induced with thiopentone 4-6 mg/kg andfentanyl 2 ug/kg and maintained with isoflurane 1.5% in gas-oxygen; group IIanaesthesia was induced with sevoflurane 8% ruing a vital capacity inhalation technique and maintained with 2% sevoflurone in gas-oxygen. In the two groups pancuronium 0.1 mg/kg was administered 3 minutes after induction of anaesthesia, and reversed with 0.04mg/kgneostigmine with 0.02 mg/kg
atropine when the TOF ratio returned to 25%. The onset time from initial administration of pancuronium to maximal block in group II was significantly shorter than that in group I (143 36 and 197 34 sec. Respectively). Also the clinical duration from maximal block to 25% recovery of TOF ratio was significantly longer in group 11 than in group I (66 13 and 44 9 min respectively). Whereas the reversal times from administration ofneostigmine to 75% of TOF ratio was slightly longer in group 11 than in group I (197 32 and 188 28 min respectively) but did not reach statistical significance. Vital capacity inhalation induction of anaesthesia with sevoflurane accelerates onset and prolongs duration of pancuronium neuromusadar
block compared to thiopentone-fentamyl-isoflurane anaesthesia.
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