Basic research in chronic otitis media with cholesteatoma
is very important as it may clarify the pathophysioiogy of the
disease and explain the wide variation in clinical course.
In the present study aggressive type cholesteatoma has
histopathological findings characteristic of human papilloma
virus induced-lesions (i.e. obvious koilocytosis) in 33.3%
specimens. Moreover 50% of the aggressive cholesteatoma
were stained positive for human papiiloma virus (HPV)
polymerase chain reaction (PCR).
Statistical correlations were established between hyperproliferation
(as revealed by MIB I high score) of the cho
lesteatoma and severe bone erosion (pave the way to major
cholesteatoma complications) and also between hyperproliferation
and middle ear inflammation (associated with more
surgical difficulties and possible higher risk of recurrences).
These findings indicate a possible relationship between
HPV with more aggressive cholesteatoma. It may arouse the
cleavage, proliferation of cholesteatomatous epithelium and
may also play a certain role in the recurrence |
