Sevoilurane degradation by carbon dioxide absorbents during low - flow anesthesia forms compound A, which causes nephrotoxicity in rats. This study was done to evaluate post operative renal and hepatic functions after patients were administered Sevoflurarte under conditions designed to generate high concentration of compound A. Consenting forty patients ASA physical status I, II with normal pre operative renal and hepatic fwiction undergoing anesthesia for elective surgery with planned duration exceeding 2 h. They were randomized to receive Sevoflararte (n=20) Or Isoflarane (n=20) in oxygen. Total gas flow was IL/ min. opioid doses were minimized and barium hydroxide lime was used to maximize anesthetic degradation. Blood and urine were obtained before and 1.2 and 3 clays after anesthesia for laboratory evaluation. Sevoflurarte and Isoflurane groups were similar with respect to age, weights sex. AM status and anesthetic duration (2-4W. There was no significant difference between anesthetic groups in postoperative serum creatinine. BUN, and urinary excretion of protein .Post operative alcmine and aspartate amino transferase concentration were not different between the anesthetic groups. It is conch wied that renal tubular and hepatic effects of low-flow Sevoilurane and Isoflurane were similar as assessed using both conventional measures of renal and hepatic functions |
