Publications of Faculty of Medicine:EFFECT OF TROPISTERONE AND ONDANSETRONE USED ALONE AND IN COMBINATION WITH DEXAMETHASONE ON THE INCIDENCE OF POSTOPERATIVE NAUSEA AND VOMITING AFTER LAPAROSCOPIC GYNECOLOGICAL OPERATIONS : Abstract

Tropisetrone either atone or in combination had observed to decrease the incidence of postoperative nausea and vomiting (PONY) by patients undergoing surgical procedures under general anesthesia. This study compared the safety and efficacy of tropisetrone 5mg. ondansetrone 4mg alone and in combination with dexamethasone. Methods: This study had a randomized, placebo-controlled design and comprised 100 non-pregnant female allocated in 5 groups (20, each) un- dergoing laparoscopic gynecological surgery under general anesthesia. Patients had received either a single bolus of tropisetrone 5mg (Group 7), ondansetrone 4mg (Group 0), tropisetrone 5mg plus dexamethasone 8mg (Group T+D), ondansetrone 4mg plus dexamethasone 8mg (Group 0+1)), or saline (Group C) given at induction of anesthesia. Results. The groups were similar with respect to demographic data and potential confounding variables. With regard to the incidence of P01VV, group 10+DI and group IT-WI were significantly superior to group T and 0, (P3<0.05). Also tropisetrone alone and in combination was non- significantly superior to ondansetrone, either alone or in combination (P2>0.05), except 18 hours after recovery of anesthesia, where the difference was significant, (P2<0.05).