Severe necrotizing pancreatitis may occur in humans after a subclintcal
and unevenVul course of Organophosphate (OP) pesticides. This study
was conducted to evaluate the role of oxidative* stress in diazinoninduced
acute haemorrhagic pancreatitis. Sixty three male guinea pigs
were divided into three groups; a negative control, a positive control and
a test group. Acute pancreatitis was induced in animals of positive control
and test groups by a sublethal dose of the organophosphate insecticide
Diazinon. Acute pancreatitis was induced in test animals under umbrella
of vitamin E to eliminate the effect of oxidative stress. Animals of the positive
control and test groups were sacrificed 0.5, 1, 2 & 6 hours after induction
of pancreatitis. Serum amylase and lipase values were measured,
the gross appearance of the pancreas was noted and pancreatic
tissue samples were taken for light and transmission electron microscopic
study. The results suggest that the use of the antioxidants offers a protective
action for partial prophylaxis against induction of acute pancreatitis
by sublethal doses of Participation of oxidative stress in the pathogenesis
of this DZ induced acute pancreatitis was also insinuated. |
