Hepatitis C virus (HCV) infects more than 170 million people worldwide and
around 20% of blood donors are seropositive by ELIZA to HCV Ab in Egypt. Renal
manifestations may be the presenting features of chronic HCV infection.
This work was carried out on 200 patients with chronic HCV in order to study
the relationship between HCV and chronic kidney Disease and to strati.6t HCV
patients according to the degree of albuminuria and to know the histopathological
changes in kidney and liver by imtnunohistochemical study. It showed that screening
for proteinuria in patients with chronic HCV is necessary due to high prevalence of
renal affection in these patients. Assessment of microalbunzinuria should be done in
these patients as an early indicator for renal affection. Albumin creatinine ratio
(AC]?,) had a good reliability as a surrogate measure for routine screening of urine
albumin excretion.
Awareness of chronic kidney disease (CKD) stage in patients with HCV and
renal affection help prediction and early management of renal disease. There was a
documented link between cryoglobulinemic and non-cryoglobulinenzic membranoproliferative
glomermlonephritis and HCV infection. |
