Aim: To assess the prognostic significance of both Vimentin
(VIM) expression and 8-100 protein positive Langerhans
cells (8-I00 PPL) in endometrial carcinomas.
Methods: Paraffin-sections from previously diagnosed
endometrial carcinoma were graded and staged according to
the recommendation of the international federation of Gynecology
& Obstetrics (FIGO 2002). Ten proliferative endometrial
cases were also used as normal control. Three sections
of 4 micron thickness were obtained for every case. One is
H&E stained for diagnosis reviewing and confirmation. The
other 2 sections are immunohistochemically stained for VIM
and S-100.
Results: The data of immunohistochemical results were
correlated with the following conventional prognostic variables:
Tumor type, grade, stage and 5 year-survival.
The results showed a significant negative correlation
between VIM positivity and VIM expression score in one side
and the tumor stage and grade in the- other (p<0.05; 0.001).
Correlating 5-year survival with VIM positivity and expression
score, they showed a significant relationship with p-value
<0.05. The: results showed also a significant and highly
significant correlation between 8-100 PPL count in one side
and endometrial carcinoma grade, stage and 5-year survival
in the other (p<0.05, <0.001 and 0.001 respectively).
Conclusion: In conclusion pronounced tumor infiltration
by Langerhans cells and VIM positivity of tumor cells may
be considered as favorable prognostic factors in endometrial
carcinoma. |
