Aim: This study aims at assessment of the role of Cyclin E and Bc1-xL in colorectal
carcinoma.
Patients and Methods: This study was carried on 50 cases offormalin-fixed paraffinembedded
tissues of colorectal carcinoma and ten normal control cases. They were
graded and staged according to grading and 7'NM staging systems. All cases were
immunohistochemically examined for Cyclin E and BcI-xL.
Results: Immunohistochemical results of both Bc1-xL and Cyclin E were correlated
with other clinicopathologic variables, tumor stage, grade, metastatic status and 5
year survival.
The results showed a signcant relationship between Cyclin E in one side and
tumor grade, metastatic status and 5-year survival in the other (P<0.5). However,
statistically it showed insignificant relationship between Cyclin E immunoreactivity
and tumor stage.
In relation to Bc1-xL immunoreactivity, it showed a highly significant correlation
with tumor stage (P < 0.01) and a significant relationship with metastatic status and
5-year survival. However, no significant relationship between Bc1-xL and tumor
grade could be detected.
Conclusion: Cyclin E overexpression could be considered as a tumorigenic factor
in the pathogenesis of colorectal carcinoma. It could be considered as one of the
prognostic factors of colorectal carcinoma. Also BcI-xL may have a role in the
pathogenesis of colorectal carcinoma and is associated with tumor progression and
poor prognosis. However, the precise mechanism of Bc1-xL underlying the
carcinogenesis of human colorectal carcinoma is still unclear, and further studies may
be needed |
