Background : Ovarian cancer remains the leading cause of death from
gynecologic malignancy in many countries .Lack of symptoms in the early
stages of disease with consequent delay in diagnosis continues to result
in poor overall survival.
Aim: The expression of cell regulatory proteins was studied in an attempt
to find the role of these proteins in differential diagnosis and progression
of ovarian tumors.
Materials and Methods : Sixty five cases with epithelial ovarian tumors
(35 serous, 24 mucirtous,4 cases endometroid carcinomas and 2 cases
were undifferentiated tumors were evaluated for expression of c-erbB-2
and bcl-2 by inunurtohistochemical technique and correlated with clinical
parameters such as type, grade, and stage.
Results : Expression of c-erbB2 was significantly differed among the
various types of ovarian tumors (p=0.01), highly expressed in undifferentiated,
high grade ,and advanced stage tumors in contrast to its weak
expression or loss in benign variety. While the bcl-2 was significantly lost
in more aggressive tumors but strong expression was observed in benign
lesions .p=0.01.
Conclusion : In ovarian tumors, proto-oncogene c-erbB-2 and antiapoptotic
gene bc1-2 hod a role in behavior and differentiation of these tumors |
