Expression of blood group antigens A , B and H was studied in
6 cases with chronic cystitis , 31 cases with squamous cell carcinoma
( S.C.C. ) , 13 cases with transitional cell carcinoma ( T.C.C. ) , 3
cases with adenocarcinoma , 2 cases with undifferentiated carcinoma
and 5 cases of normal urinary bladder epithelium as control - using the
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.942
immunoperoxidase staining via pe:oxidase antiperoxidase ( PAP )
technique . It was found that the areas of chronic cystitis retained A, B
and H antigens similar to the control ( normal urinary bladder epithelium
) while in patients with S.C.C., 55% of the patients with grade I
tumours , 82% with grade H and 89% with grade HI tumours had loss
of cell surface antigens and 29% of the cases expressed H - antigens in
the areas of S.C.C.
In patients with T.C.C., 50% of the patients with grade I tumours,
75% with grade II and all patients with grade III tumours had loss of
cell surface antigens and 38.5% of the cases demonstrated H - antigens
in the areas of T.C.C.
All cases of undifferentiated carcinoma had loss of cell surface
antigens . In contrast , cases of adenocarcinoma showed loss of
isoantigens in 2 cases of grade I and expressed them in grade II
tumour. Sixty seven percent of the cases expressed H antigens in
the areas of adenocarcinoma . The adjacent areas to carcinoma whether
S.C.C. or T.C.C. were regaining the normal antigen and losing
the H - antigen gradually as one goes from the micro - invasive area
to areas of carcinoma in situ, dysplasia and back to normal epitheli-
UM .
This study suggests that expression of A, B and H . blood group
isoantigens in the urinary bladder carcinoma ( S.C.C. or T.C.C. ) is
correlated to the grade of tumour and tends to be lost as the histological
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943
grade increases . Patients with blood group 0 were more susceptible to
loss of blood group isoantigens.
Further studies are recommended to correlate between A , B & H
isoantigens with the prognosis . |
