Thirty-six male adult rats weighing 200-250 g. were used in this study. They were
randomly divided into 3 equal groups. 1st group served as a control, in the second
group, the rats were daily injected intraperitoneal with morphine for 7 consecutive
days at a dose 30mg. / Kg body weight /day. The animals of third group were injected
with morphine as the previous group and then the drug was arrested for another two
weeks.
The observed histological changes were in the form of irregularity of the
seminiferous tubules and degenerative changes in the spermatogenic cells. The
epididymis showed irregularity in the thickness and decrease of sperms in the lumen.
No changes occur in the connective tissues contents at any group.
The Histochemical changes were in the form of increase in PAS and acid
phosphates enzyme activity and decrease in alkaline ph. Enzyme activity in the testis
and epididymis.
In the morphine withdrawal group the tissue regain their normal histological structure
and the enzymes regain their normal activity |
