During the fertile age women showed a lower serum w-ate than men of
similar ages. The intersexual difference is thought to be related to a higher
renal clearance of urate possibly due to their higher plasma oestrogen
level. We correlated between the cyclic changes of S. oestrogen and S.
Uric acid during the menstrual cycle. S. oestrogen and S. uric acid were
estimated at days 1. 7, 14. 21 and 28 of menstrual cycle in 20 normal
age-fertile non married women. The progressive rise of S. oestrogen in the
1st half of the menstrual cycle was accompanied by a progressive decrease
of S. uric acid and its progressive decrease in the 2nd half was accompanied
by a progressive increase in S. uric acid. S. uric acid changes
were plotted as a curve which is nearly a mirror of the S. oestrogen curve
and so it could be used to give an idea about the physiologic oestrogen
curve in females. The correlation test betwgen the two curves indicated
that the suggested influence of S. oestrogen on S. uric acid is neither direct
nor absolute, perhaps through a physiological mechanism including
more than one factor in add Won to S. oestrogen. |
