Publications of Faculty of Medicine:THE EFFECT OF ORAL CLONIDINE PREMEDICATION ON THE INDUCATION DOSE AND AWAKENING TIME IN PATIENTS TAKING PROPOFOL NITROUS OXIDE ANAESTHESIA. HIGH DOSE CLONIDINE VERSUS LOW DOSE CLONIDINE : Abstract

We compared the effect of 2 differet doses of oral clonidine used as premedication on the inducation dose and recovrey in patients taking pro pofol nitrous oxide anaesthesia .50patients were randomly allocated to receive 5ug/kg clonidine arolty fn=25 group I) or 2.5ug/kg clonidine (n=25 group) 90minutes before the induction of anaesthesia After epidural an aesthesia was achieved with lidaccdne, general anaesthesia was induced with continous intravenous propofol at a rate 50mg/minute until the loss of eye lash reflex and response to verbal commands, which were judged by blinded observer. After laryngreal mask insertion, anaesthesia was maintained with nitrous oxide 60,02 40%and propofol was adjusted to maintain haemodynamic stability. After the end of surgery, we recorded the time from the discontinuance of propofol and nitrous oxide until the patient was awake and responsive (awakening time) and after that the larynbeal mask was removed. The inducation dose was reduced in group I compared to group U. The awakening time was prolonged in group I pre medication with 5ug/kg reduced the induction dose and prolonged the awakening time compared to oral chonidine dose of 2. 5ug/kg.