The efficacy of 0.125% of levopubivacaine with 0.125% of Racemic bupicacaine in providing labour analgesia combined with sufentanil 0.75 µg/mL were compared as a part of combined spinal epidural technique. Sixty term parturient received either levobupivacaine or racemic bupivacaine in a randomised double blind study. Two mL. of this mixture was Initially injected Intrathecally, and the same mixture was subsequently adinin!stered -epidurally In boluses of 10 mL. Onset until the first painless contraction was 5±2.1 min. for levobupivacaine and 4.8±2.1•min. for racemic bupivacaine. The duration of Initial spinal analgesia was 92.5±22.5 min for levobupivacaine and 94.5±28.5 min for racemic bupivacaine. The-duration of analgesia for the 'first top-up epIddral dose was 105 ± 19 min for levobupivacaine and 107 ± 24 min for racemic bupivacaine. The only major difference observed was the absence of motor block in levobupivai..t treated parturient as compared with racemic bupivacaine group (Bromage-1 motor block• , vs 0%, 35% respectively). Other side effects and obstetric or neonatal outcome were. comparable in both groups. Levobupivacaine injected as a part of combined spinal epidural technique has a similar clinical profile as a racemic bupivacaine, but it produced less motor effects at equal doses and concentration. |
