Sevoilurane degradation by carbon dioxide absorbents during low - flow anesthesia forms compound A, which causes nephrotoxicity in rats. This shay was done to evaluate post operative renal and hepatic functions after patients were administered Sevofiurane under conditions designed to generate high concentration of compound A. Consenting forty patients ASA physical status I, II with normal pre operative renal and hepatic function undergoing anesthesia for elective surgery with planned duration exceeding 2 h. They were randomized to receive Sevoflarane (n=20) or Isoflarane (n=20) in oxygen. Total gas flow was IL/ min. opioid • doses were minimized and barium hydroxide lime was used to maximize anesthetic. degradation. Blood and urine were obtained before and 1,2 and 3 days after anesthesia for laboratory evaluation. Sevoflurane and Isoflurane groups were similar with respect to age. weights sex. ASA status and anesthetic duration (2-4h). There was no significant difference between anesthetic groups in postoperative serum creatinine, BUN, and • urinary excretion of protein .Post operative alanine and aspartate amino transferase concentration were not dlfferent between the anesthetic groups. It is concluded that renal tubular and hepatic effects of low-flow Sevofiurane and Isoflurane were similar as assessed using both conventional measures- of renal and hepatic functions .Moderate duration of lowflow Sevofiurane anesthesia |
