This study was done to evaluate the effect of IV lidocaine onfentanylinduced cough and to determine the minimal dose of IV lidocaine required for suppression of fentanyl-induced cough. For this purpose, 400, non smoker patients between the ages of 13 and 65 years with ASA I and II were scheduled for elective surgery and included in the study. The pa tients were randomly divided into four equal groups. The patients in group I received intravenous lidocaine, 0.5 mg-kgl, those of group II re ceived intravenous lidocaine 1.0 mg-kgl, those of group HI received intra venous lidocaine 1.5 mg-kgl, while group IV was a placebo group. Any episode of cough was classified as coughing and graded as mild (1-2) moderate (3-4) or severe (5 or more). The data were analyzed by test of proportion. Twelve, 14, 12 and 36 patients (12%, 14%, 12% and 36%) had cough in groups I, II, III and TV respectively (P < 0.05 in groups I, U, III vs. IV). There was no significant difference in the incidence and severity of cough among the lidocaine preheated groups (P > 0.05). The results of our study suggest that IV lidocaine 0.5 mg-kgl is the minimal dose re quired to suppress Fentanyl-induced cough when administered one min ute prior to Fentanyl Any further increase in the lidocaine dose does not reduce the incidence or severity of Fentanyl-induced cough |
