We designed this study to compare the analgesic and haemodyncunic effects of Icetamine and magnesium sulphate given intravenously before intravenous morphine. (60) female patients undergoing open cholecystectorny were randomized into 4 groups (n=15), group I (control) patients received 20 ml saline 3 min before induction and 10 ml every 6 hs for 24 hs postoperatively (p.o), group II patients received 25 mg/kg magnesium sulphate in 20 ml saline 3 min before induction and 1 gm in 10 ml saline every 6 hs for 24 p.o, group III received 50 mg / kg magnesium sulphate in 20m1 saline 3 min. before induction and 1 gm in 10 ml saline every 6 hs for 24 hs p.o, group IV received 25 mg ketamine in 20 ml saline 3 min before induction and 25 mg in 10 ml saline every 6 hs for 24 hs p.o. After surgery patients stayed in the recovery room for 24 its. Morphine requirements, 24 h p.o, which keep visual analogue scale (VAS) at 30 or less were calculated, also, need for nasal oxygen to maintain capillary oxygen saturation above 95% was recorded , heart rate and mean blood pressure were monitored continuously and recorded every 3 hs for 24 hs p.o. Pain at rest, peak flow rate and discomfort were evaluated after 6,12,18 and 24 its p.o. Quality of sleep was evaluated in the morning after the first p.o night |
