Background: Rocuronium bromide is a non-depolarizing muscle relaxant (NDMR). It has a fast rate of onset of action, intermediate duration and rapid recovery. Mivacuriwn is a short acting (NDMR) that undergo rapid breakdown by plasma cholinesterase leads to rapid spontaneous recovery. In this study rocuroniurn, in two small doses 0.3 and 0.45mg/ kg were compared with mivacurium 0.2rng/ kg as regard, intubations, onset, clinical duration and reversal either spontaneous or induced, using neostagmine and glycopyrrolate. Method: This study divided into two parts. In part I, quality of neuromuscular block for intubation was studied, 90 patients were allocated randomly to one of three groups (n=30) to receive rocuronium 0.3mg/ kg (group /), rocuronium 0.45rng/ kg (group 2) and mivacuriurn 0.2mg/ kg (group 3). Fnch group divided into two equal subgroups (a & b). The trachea was intubated after 60sec in subgroups la & 2a, after 90sec in subgroup lb, 2b & 3a and after 120sec in subgroup 3b. Intubating conditions were graded as excellent, good or poor. In part II, assessment of onset, clinical duration and time for reversal were studied. 90 patients were randomly assigned to one of three groups (n=30), group I received rocuronium 0.3mg/ kg, group /I received rocuronium 0.45mg/kg and group III received mivacurium 0.2mg/ kg. The onset, maximum degree of block and clinical duration were measured. When T25 was reached, the three groups divided into equal subgroups a & b. Subgroups Ia. Ha and lila undergo spontaneous recovery and subgroups lb |
