The adequacy of postoperative laparoscopic cholecystectomy pain con trol is one of the most important factors in determining when a patient can be safely discharged from the outpatient facility. The purpose of this study was to compare the quality of analgesia and side effects of intrave nous paracetamol (perfalgan} I g versus intravenous meperidine 100 mg for postoperative analgesia after ambulatory laparoscopic cholecystecto my. The study comprised eighty patients, ASA physical status I or II, age 20-60 years, undergoing elective cholecystectomy under general anesthe sia at Benha University Hospital Before the end of the operation and af ter removal of the gall bladder, patients were randomly allocated to one of two equal groups, (Group 1) patients received lg/lOOmll.V. paraceta mol (Perfalgan] in 15 minutes and (Group. 2) patients, received 100 mg meperidine (pethidine) I.V. in 15 minutes. Most of the patients (72.5%) in paracetamol group had a VAS Score more than five at six hour after the operation. But in meperidine group (Group 2) the pain intensity increases after 15 minutes and made apeak level in the second hourdfter the oper ation. Patients with a VAS score more than five a rescue analgesic was given to the patient. The time to the first request for supplemental analge sia after injection of the study drugs was approximately three times long er in the paracetamol compared with meperidine. Total analgesic con sumption 24 hours postoperatively was higher in meperidine group. 16 (40%) of patients in meperidine group (Group 2) were taken three doses of rescue analgesic but 12 (30%) of patients in paracetamol group (Group 1) take three doses of rescue analgesics |
