Postdural puncture headache (PDPH) is one of frequent adverse compli cation qfdural puncture. Although, it is a self limiting and non-fatal condi tion, its postural nature prevents the patient from performing routine ac tivity and may make them anxious and depressed. In this study we evaluate a combination of sumatriptan and gabapentin for treatment of PDPH and compare it with sumatriptan or gabapentin as sole medication. ASA I &.II 45 patients age between 20 and 40 years and non-parturient, who's developed PDPH after spinal or epidural neuraxial block was in cluded in the study. Patients were randomized to receive either gabapen tin 300 mg orally every 8 hours for one week group I. in group 11 patient was received sumatriptan 50 mg orally once daily for 3 successive days. In group III, patients received sumatriptan 50 mg orally every day for 3 days and gabapentin 300 mg every 8 hours for 7 days. PDPH was evalu ated by using Visual Analog Scale (VAS). measured 20 min after patients assumed upright postures either sitting or standing. It was recorded be fore start the treatment as baseline and at 12, 24, 36, 48, 72 and 96 hours after. Satisfaction of patients with treatment was asked, after 4 days. Complications such as somnolence, dizziness, seizures, chest pain, nausea, vomiting and dry mouth were recorded. VAS was significantly low and patient satisfaction was high in group III when compared with the other two groups. Number of patients reported somnolence and dizzi ness were significantly high in group III compared to group I or II. Combi nation of sumatriptan and gabapentin could be beneficial for treatment of patients with PDPH, |
