Publications of Faculty of Medicine:EFFECT OF BOLUS DOSE REMIFENTANIL ON HAEMODYNAMIC AND INTRAOCULAR PRESSURE RESPONSES TO TRACHEAL INTUBATION AND EXTUBATION DURING RAPID SEQUENCE INDUCTION AND RECOVERY OF ANAESTHESIA : Abstract

The effect of bolus dose of rernifentanil on the pressor responses to laryngoscopy and tracheal intubation or extubation during rapid sequence induction and recovery of anesthesia was assessed in a randomized, double- blind, placebo- controlled study in two groups of 20 patients each. No premedication was given. Anesthesia was induced with thiopental 5mg / kg. Followed by saline placebo or remifentartil 1.5 pg /kg and suxamethonium. After the trachea get intubated, anesthesia maintained with isoflurane and nitrous oxide in oxygen, at the end of surgery irthalational anesthesia discontinued, the study drug readministered and residual muscle relaxant was reversed. Mean arterial blood pressure, heart rate and intra-ocular pressure were recorded immediately before induction, before irttubatthn, at interval until 5 min after treachecd intubation, before extubation and then at interval until 5 min after tracheal extubation. There was a significant decrease in mean arterial pressure (MAP), heart rate (1-IR) and irttraocular pressure in remifentand group (group R) compared with saline placebo group (group S) from time of administration of the study drugs to the end of the study at 5th min after extubation (Pc 0.001). we conculoded that remifentanil 1.5 pg/ kg administered during induction and recovery, prevented the pressor response and increase in lOP after irttubation or extubation.