Publications of Faculty of Medicine:INTRAVENOUS DEXMEDETOMIDINE IS EFFICIENT PROPHYLAXIS AGAINST POST-ANESTHESIA SHIVERING WITH RESCUE-TREATMENT SPARING EFFECT : A COMPARATIVE PLACEBO-CONTROLLED STUDY VERSUS MEPERIDINE AND KETAMDJE: Abstract

This study aimed to evaluate the effect of dexmedetotnidine and ketamine on the frequency and severity of post-anesthetic shivering (PAS) in comparison to meperidine as negative and saline as positive control drugs. The study comprised 80 patients assigned to undergo abdominal or pelvic surgery under general anesthesia. Patients were randomly allo cated into 4 equal groups (n=20) received intravenous injection of either saline (Croup S), meperidine 20 mg (Group M), ketamine 0.5 mg/kg (Croup K) or dexmedetomidine 1 yg/kg (Group D), all drugs were given as a 10-ml injection, 20 minutes prior to the end of surgery. In postanesthesia recovery unit (PACU], all patients were monitored noninvasively for heart rate, blood pressure, oxygen saturation and core tem perature measured at the tympanic membrane using an ear thermometer (Thermoscan IRT 3020; Broun, Kronberg, Germany). Post-anesthetic re covery was scored using the Observer's Assessment of Alertness/ Sedation (OAA/S)score on arrival to PACU. The severity of PAS was eval uated using five grades scale: on admission to PACU (TO), 10 min (T10), 20 min (120) and 30 min (T30) after admission. Nefopam was given 10 mg IV at PAS score of 2. Any possible side-effects of the study drugs were recorded. In group S, 18 patients had PAS; 15 required treatment but 3 patients did not require and the other 2 patients had no PAS. In group K, 11 patients had PAS score of zero, 6 patients had PAS scored one and the other 3 patients had PAS scored >2 and required treatment Only 3 patients;