The objective of this study was to compare the efficacy of antiemetic effect of dexamethasone and granisetron used alone and in combination for prevention of postoperative nausea and vomiting (PONV) following laparoscopic cholecystectomy (LC). Patients 8t Methods: The study comprised 80 patients scheduled for LC and randomly allocated into 4 equal groups, (n= 20, each): group D: received IV dexamethasone (8 mg), group C: received IV granisetron (3 mg), group D+G: received IV dexamethasone (8 mg) and granisetron (3 mg),and group C which received IV normal saline over 60 seconds imme diately before induction of general anesthesia. The severity of all epi sodes of PONV was recorded throughout thefrrst 24 hours after surgery. Nausea was scored as 0=nil, l=mild, 2^moderate, and 3=severe nausea and vomiting was scored as 0=nil, l=one mouthful vomttus, and 2=more than one mouthful ofvomitus. Complete response (le., emesis-free) was defined as no PONV and no need for another rescue medication. Patient's requests for rescue anti-emetics and adverse events were recorded. |
