This study was designed to evaluate the impact qfepidwal naloxone (N) or droperidol (D) on the outcome ofepidwaL morphine analgesia. The study comprised 60 females assigned to undergo abdominal hysterecto my randomly allocated into three equal groups (n=20), each received med ication mixture via infusors: Group M received 3 mg morphine in 100 ml bupivacaine 0.125% at rate of 2 ml/hr; group M+N and M+D received the same mixture, but with the addition of naloxone so as to provide an infu sion rate of 0.167 pg/kg/hr of naloxone in group M+N or droperidol in a dose of 1.25 mg/day continuous infusion in group M+D. Pain sensation was evaluated using 100-nvn visual analogue scale, postoperative nau sea and vomiting (PONV) was monitored on a four-point scale: 0: no, 1: mild not requiring an antiemetic, 2: moderate requiring an antiemetic and 3: severe nausea/vomiting, resistant to antiemetic. Pruritus was evaluated using a four-point scale: 0=no, 1= mild, 2 moderate & 3= se vere itching. Somnolence was graded as follow: l=clear mentality, 2= good response to verbal command but drowsy & 3= poor response to re peated verbal command. Respiratory depression was assessed as 1= no respiratory depression & 2= respiratory depression exists with a respira tory rate<8 breaths/min All parameters were assessed at 2, 4, 8, 16, 32, and 48 hr PO. At 8-hrs PO, VAS scores were significantly lower in M+N (PI =0.017) and M+D (PI =0.034) groups compared to group M., |
