Objectives: The present study aimed tolestimation of tissue extract epidermal
growth factor receptor (EGFR) and serum squamou_s cell carcinoma.
antigen (SCCA) levels in patients with inverted papilloma (IP) in varied
pathological states as a trial to determine their role in pathogenesis and/
or their applicability for differentiation between these different patho/ogical
changes. •
Patients & Methods: The study included 6 cases with primarily diagnosed
IF. 4 cases with recurrent IF and 3 cases had IF with SCC and 10
healthy volunteers to give blood samples as control group. All patients underwent
full history taking. general and local examination and CT irnag- •
ing was conducted. All cases underwent endoscopical excision and freshly
excised IF tissues were divided into two parts: the first for
histopathological examination and the second was immediately frozen on
dry ice and stored in liquid nitrogen at -70°C until processed for estimationof
tissue extract level of EGFR. Venous blood samples were obtained
prior to and after surgical resection for ELISA estimation of serum SCCA.
Results: The study included 13 patients: 10 males and 3 females.
with mean age of 62.4+6.2 years. Nasal obstruction was the main presenting
symptom followed by epistcods arid headache. Patients with recurrent
IF gave history of previous endoscopic removal since a mean duration
of . 6.24-2.2 months and one patient had recurrent IF twice.
Histopathological examination documented the diagnosis of benign IP in
10 cases and SCC changes in 3 IP. Mean EGFR levels estimated in tissue
extract of IP with SCC was signOcantly higher compared to benign IF
with significantly higher levels in recurrent IF compared to primary IP. |
