The present study was undertaken to evaluate the changes in liver.
muscle and serum triglycerides during high sucrose feeding and relationship
of these changes to the appearance of insulin resistance and also to
demonstrate if sex steroid hormones would protect against sucrose induced
insulin resistance. 70 male and 70 female rats of the same age.
weight and strain were included in this study All rats were housed individually
and were given high starch diet (6896 corn starch. 20% protein
and 12% fat) for 1 week, then half of rats ( 35 male rats and 35 female
rats) remained on the high starch diet for 2,5 and 8 week while the other
half of rats were shifted to a high sucrose diet (68% sucrose. 20% protein
and 12% fat) for 1,2,5 and 8 week. 11 male rats and 10 female rats were
excluded from our study because their food intake was less than 90% of
that provided Serum glucose ,insulin and triglycerides were estimated
with liver and muscle triglycerides. In female rats, there were non significant
changes in serum glucose. serum insulin, serum triglycerides, liver
and muscle triglycerides between high sucrose diet and high starch diet
at /,2,5 and 8 week. In male rats fed sucrose diet, there was significant
increase in serum insulin level at 2,5 and 8 week compared with high
starch fed rats, but there was non significant change in serum glucose between
both groups. Serum and liver triglycerides were signficantly increased
in male rat fed sucrose diet at 2.5 and 8 week compared with
starch fed male rats. We concluded that, high sucrose diet produces insulin
resistance in male rats which is related to change in triglycerides concentration
and female rats in contrast to male rats do not develop sucrose
47
Ashraf Bela! and Medhat Abd El-Moneim
induced insulin resistance or hypertriglyceridaemia and the presence of
estrogen and or progesterone or absence of male. hormones may be protective
in female rats against the impairment of insulin action on a high |
