The effects of estrogen receptor blockage by tarnorcifen on testicular
function and reproduction were evaluated in mole albino rats. Tamoxifen
treatment in two doses ( 100 and 400 ug / d ) and for different periods (
10,20.60 and 90 days) resulted in an initial increase in serum FSH levels
( after 10 and 20 days of treatment), which returns back to the control
level after 60 and 90 days. Serum LH, serum testosterone and testicular
testosterone levels are all decreased by tarnoxifen treatment . The decreased
serum LH suggests that tcunoxifen may act as estrogen agonist
at the hypothalamo-pituitary axis, inhibiting pituitary LH secretion. Tamoxifen
decreased both serum and testicular testosterone levels and altered
testicular weight and spermatogenesis, resulting in decreased
sperm count and increased sperm abnormalities and acrosomal damage.
It could be concluded that, endogenous mole estrogen is an important
male hormone and estrogen receptor blockage by tamoxifen decreased
male fertility . |
