Background: Fungi have been increasingly recognized as important
pathogens in sinusitis. Fungal infection mainly by moulds, can impose a
severe acute and chronic sinusitis in the irnmunocompromised host as
chronic myeloid leukemia.
Polymerase Chain Reaction (PCR) is an important tool in diagnosis of
fungi even in small amount in the secretions.
Objective(s): is to detect the causative pathogenic fungi in chronic maxillary
sinusitis in cases of chronic myeloid leukemia patients by using
PCR technique.
Patients and Methods: 20 patients of chronic myeloid leukemia suffering
from maxillary sinusitis and 20 patients with chronic maxillary sinusitis
not suffering from any immunocompromised disease were used as
control group, both groups were subjected to intranasal antrostomy then
.antral lavage were subjected to fungal culture and PCR techniques.
Result(s): PCR detect 80% positive fungi in test group but there was
negative in control group, Aspergillus spp., A. fumigatus and Penicilliurn
spp. and Candid° were present in positive cases, 20% of cases were detected
by simple fungal culture.
There is significant difference between PCR and fungal culture
(P<0.05)
Conclusion (s): PCR technique is sensitive tool in diagnosis of fugal infection
in chronic maxillary sinusitis in patients with chronic myeloid leukemia:
PCR is superior to ordinary fungal culture and can detect fungi
even in small amount offungal spores. Aspergillus spp., |
