Background: Otitis media (OM) has the highest incidence among all
medical conditions in children younger than age five, Otitis media with ef -
fusion (OME) is the most common cause of childhood deafness. Castroesophageal
reflux disease (GERD) refers to the symptoms and complications
of abnormal passage of gastric contents into the esophagus. Laryngopharyngeal
reflux (LPR) is the movement of gastric contents beyond the
esophagus up to the laryngeal and pharyngeal area. As well as pepsin
and acid of gastric contents can include bile acids and pancreatic enzymes,
all of which can injure tissues not adapted to them. Although Gasteroesophogeat
Reflux(GER)may be normal, LPR (Laryngopharyngeal Reflux)
should never be considered physiologic.LPR has been implicated in
the OME pathogenesis; therefore, it is necessary to identify the presence
or absence of gastric juice in the middle ear.
Hypothesis: The objective was to investigate the potential use of pepsin
and pepsinogen as diagnostic marker for Laryngopharyngeal reflux
disease in otitis media with effusion
Study design: We studied 100 children with symptoms suggestive of
either gasroeosophgeal reflux (GER) or OM clinically; all patients were
subjected to pharyngeal PH test,Tympanometry, middle ear fluid samples
(obtained by myringotomy from patients with Otitis media with effusion)
were examined for the presence of pepsin and pepsinogen by using a proteolytic
enzyme assay |
