Background: Since morbidity and mortality rates due to oral cavity
and oropharyngeal squamous cell carcinoma (OSCC) have improved little
in the past 30 years, early detection or prevention of this disease is likely
to be most effective. Interleukin (IL) 6 is one of these cytokines may contribute
to the pathogenesis of this disease, and have been linked with increased
tumor growth and metastasis.
Objectives: To investigate the role of interleukin 6 in prognosis of oral
squamous cell carcinoma.
Patients and Methods: the study included 20 patients with oral
squamous cell carcinoma (OSCC) T1 and T2, they were subjected to surgery,
serum interleukin 6 were estimated before one week before surgery
and 6 month after surgery by using Enzyme-linked immunosorbent assay
(ELISA) technique. 10 normal subjects were used as control group.
Results: there were significant difference of interleukin 6 serum level
one week before and after 6 month of surgery (p<05) and significant difference
between one week before surgery and control group while insignificant
difference between control group and 6 month after surgery.
Conclusion: our findings showed that serum interleukin 6 present in
high levels in oral squamous cell carcinoma and decreased after eradication
of the disease so it hold promises as biomarker for oral squamous
cell carcinoma and it is effective adjunctive tool in the follow-up patients
with OSCC. |
