Basic research in chronic otitis media with cholesteatoma is very important as it
may clarify the pathophysiology of the disease and explain the wide variation in clinical
course.
In the present study aggressive tylie cholesteatoma has histopathological findings
characteristic of human papilloma virus induced-lesions (i.e. obvious koilocytosis) in
33.3% specimens. Moreover 50% of the aggressive cholesteatoma were stained positive
for human papilloma virus (HPV) polymerase chain reaction (PCR).
Statistical correlations were established between hyperproliferation (as revealed by
MIB 1 high score) of the cholesteatoma and severe bone erosion (pave the way to major
cholesteatoma complications) and also between hyperproliferation and middle ear
inflammation (associated with more surgical difficulties and possible higher risk of
recurrences).
These findings indicate a possible relationship between I WV with more aggressive
cholesteatoma. It may arouse the cleavage, proliferation of cholesteatomatous epithelium
and may also play a certain role in the recurrence of the disease following well performed
surgical excision. |
