Total IgG, 19A, IgM, IgG subclasses IgG 1. IgG2, Ig03. IgG4 and antipneumococcal
antibody titers were measured in 25 patients with recurrent
acute otitis media (r-A.O.M).
There was no significant difiference between patient population and
control group as regard to the total IgM, IgA. IgG and 19G subclasses Ig
G3 ez. Ig04 whereas IgG 1, IgG2 shows a significant difference. Low 1901
and IgG2 has been associated with impaired immune responsiveness to
polysacchride antigens.
Children who had normal immunoglobulin 10G. IgA, 1gM and subclass
levels but had a defect in the production of antibodies specific for pnew
mococcal capsular antigens had been identified.
We recommended (1) Further studies to involve a big number of cases
to evaluate the immune aspects of recurrent acute otitis media especialy
the selective deficiency of specific pneumococcal antibodies .(2) trials of
polyvalent artticapsular polysaccharide vaccines for patients older than 2
years with low peneumococcal antibody titers and (3) passsive immuneprophylaxis
can be applied to children under 2 years old suffering from
IgG 1, IgG2 with low or no specific antipneumococcal (or anti. H. influenzae)
antibodies. |
