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Prof. Yasser Haroun Mohamed Abo-Essa :: Publications:

Effect Of Chitosan On Bone Restoration In Nasal Bone Defect (an experimental study)
Authors: Mosaad Elsisy MD, Ashraf Elhamshary MD, Yasser Haroon MD & Samira Sallam MD* Departments of Otorhinolaryngology & Physics*, Faculties of Medicine & Sciences*, Benha University, Egypt
Year: 2013
Keywords: Not Available
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Local/International: Local
Paper Link:
Full paper Yasser Haroun Mohamed Abo-Essa_3.pdf
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Abstract Objective: The aim of this work was to study the effect of chitosan in restoration of bone defect (an experimental study). Materials and methods: The study included 54 male guinea pigs. Nasal bone defect was done. The experimental animals were divided into a control group (A), calcium sulphate group (B) and chitosan coated calcium sulphate group (C). Three dimensional computed tomography (3D, C.T) and histological examination were done at intervals of 1, 2 and 3 months for measuring the change in the size of the bone defect and confirmation of bone formation respectively. Results: The decrease in the size of the bone defect was significant in group (C) than groups (A & B). Also histological results showed formation of woven bone after one month in groups B & C and formation of lamellar bone in group C in the 2nd month while the lamellar bone was formed in group B in the 3rd month. Conclusion: Radiological and histological studies showed that the new bone formation on defected nasal bone was more in group (C). These findings suggest that chitosan is very effective in early bone formation. Key words: Chitosan, guinea pigs, bone formation

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