Clinical, Biochemical and Histopathological Study On Parasitic Gastroenteritis Caused By Caprine Coccidiosis: Comparative Therapeutic Effect Of Toltrazuril And Propolis. Published in the veterinary Symposium entitled "Progress and Perspective in Veterinary Medicine" Faculty of Veterinary Medicine, UASVM Iaşi, Romania 4-5 June 2009 (Volume 52 (1): 565-580)
|Authors:||Mohamed M Ghanem, Afaf Desoky and Mohamed ramadan|
|Paper Link:||Not Available|
|Full paper||Not Available|
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This study investigated the gastroenteritis caused by coccidial infection in domestic goats (Capra hircus) managed under three different rearing systems (intensive, semi-intensive, and extensive) at Kalubyia governorate, Egypt. Eimeria oocysts were found in 93 (66%) of the 141 faecal samples examined. Six species of Eimeria were morphologically identified; E. hirci (90.32%), E. arloingi (83.87%), E. alijevi (75.27%), E. christenseni (63.44%), E. caprina (29.03%), and E. ninakohlyakimovae (24.73%). Up to six Eimeria species were recorded form individual specimen. The infection rates and the mean number of oocyst outputs (OPG) decreased with increasing age of goats; 80% and 31758.08 for kids; 72.92% and 19543 for young; and 30.30% and 1769.92 for adult goats, respectively. For treatment study, 4 groups of kids were used, each of 5. The first group has 5 apparently healthy kids used as control (CH). The second group involved 5 naturally infected kids and left untreated (IN). The third group included 5 naturally-infected kids and treated with Toltrazuril (20 mg/kg body weight, orally for 2 weeks). The fourth group had 5 naturally infected kids treated with Propolis (1ml of 3% aqueous solution /liter of drinking water for 7 days). The result showed that Toltrazuril was highly effective as anticoccidial drug (94.33% reduction of OPG) than Propolis that moderately reduced OPG (54.66%). The efficacy of both drugs was further compared based on antioxidant assays, serum biochemical analysis and histopathological changes. There was a significant reduction (P> 0.05) in erythrocyte reduced glutathione (GSH), glutathione reductase (GR-ase), superoxide dismutase (SOD), catalase activities, serum albumin, A/G ratio, calcium, sodium and potassium in Eimeria-infected kids compared to control. On the other hand, significant elevations (P> 0.05) in serum malondialdehyde (MDA), iron and nitrate were recorded in infected animals compared to control. The total protein and phosphorus showed non-significant decrease compared to control. Propolis and Toltrazuril treatment significantly alter the serum biochemical aberrances toward the control values. However, Toltrazuril was more efficacious than Propolis as anticoccidial drug. To the best of our knowledge, this is the first investigation on goat Eimeria prevalence and treatment in Kalubyia Governorate.