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Dr. Ahmed Medhat Ahmed Hegazy :: Publications:

Title:
Effects of benzo(a)pyrene on blood components, tumor markers, and oxidative status in mice
Authors: A M Hegazy , H.H. Bakry , R.M. El-Shawarby , M.E. Abou-Salem , N.M. Abd El-Aleem and S.M. Nasr
Year: 2012
Keywords: benzo(a)byrene; mice; hemogram; oxidative stress; tumor markers; residues
Journal: Toxicological & Environmental Chemistry
Volume: 94
Issue: 1
Pages: 136-145
Publisher: Taylor & Francis
Local/International: International
Paper Link:
Full paper Ahmed Medhat Ahmed Hegazy_Hegazy et al._benzo(a)pyrene.pdf
Supplementary materials Not Available
Abstract:

This study was carried out to investigate the effect of long-term exposure to benzo(a)pyrene (B(a)P) in mice. Hemogram, tumor markers, oxidative status, and B(a)P residues in liver tissue were evaluated. Sixty albino Swiss mice were randomly distributed equally into three groups; the control was given 0.1 mL corn oil once a week for 8 weeks. The other two groups were given 20 and 40 mg B(a)P per kg body weight once a week orally for the same period. B(a)P-treated mice suffered from depression and ascites, and macrocytic normochromic anemia was recorded at the 16th and 30th week. There was marked leukocytosis with lymphocytosis at the early stage of the experiment, followed by leukopenia, lymphopenia, and neutropenia at the end of the experiment. Monocytes and arginase activity were elevated throughout the experiment. Alpha feto-protein was detected only in the experimental groups in the 30th week of the experiment. A marked increase in lipid peroxides associated with a decrease in reduced glutathione and glutathione-S-transferase (GST) activity was observed in liver homogenate of the B(a)P-exposed animals. Residues of B(a)P were detected in liver tissue with a concentration parallel to the B(a)P dose level. In conclusion, B(a)P caused abnormal changes in the hemogram, evidence of tumor formation through B(a)P-induced oxidative stress, and it was accumulated in the liver tissue of mice.

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