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Dr. Ahmed Masoud Sayed-Ahmed :: Publications:

Outcome of left atrial appendage occlusion in high-risk patients
Authors: Masoud A, Bartoletti S, Fairbairn T, Khurana A, Velavan P, Morrison WL, Khalatbari A, Aggarwal S, Sharma N, Kirchhof P, Gupta D
Year: 2018
Keywords: atrial fibrillation; stroke
Journal: Heart
Volume: 104
Issue: 7
Pages: 594-599
Publisher: BMJ
Local/International: International
Paper Link:
Full paper Not Available
Supplementary materials Not Available

OBJECTIVE: Percutaneous left atrial appendage (LAA) occlusion can be an interventional alternative to oral anticoagulation for stroke prevention in patients with atrial fibrillation. METHODS: We delivered LAA occlusion therapy using a standardised approach to patient referral, multidisciplinary team assessment, implant criteria, imaging and follow-up. We analysed patient characteristics, efficacy and safety of the implant procedure, and 12-month outcomes. RESULTS: Of 143 referrals from October 2014 to December 2016, 83 patients (age 76±8years, 32.5% female, mean CHAD2S2-VASc score 4 ±1) were offered LAA occlusion. Eighty (95.3%) had previous major bleeding (intracranial in 59%). LAA occluder implantation with an Amulet device was successful in 82 (98.8%), with periprocedural major adverse events occurring in 5 (6.0%) patients (2 device embolisations including 1 death, 2 major bleeds). Cardiac imaging in 75 (94%) patients 2months following implant showed device-related thrombus in 1 case (1.3%) and minor (

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