Background: Magnesium sulphate has been used along with local anesthetics in different regional blocks and found to be have agreat effect in decreasing the time of onset of the block , IOP and increasing the duration of the block. To evaluate the effect of addition of magnesium sulfate to local anesthetics mixture on the time for onset of the globe and lid akinesia ,IOP and duration of peribulbar block in differnet ophthalmic surgeries . A systematic literature search that performed to identify randomized controlled trials that compared addition of magnesium sulphate to local anaesthetics in peribulbar block against standard local anaesthetic in different eye surgeries . Using the random effects model, risk ratio (for binary variables), weighted mean difference (for continuous variables) and 95% confidence intervals were calculated.We applied trial sequential analysis to assess the risks of type I and II error, meta-regression for the study of the doseresponsive relationship, and the Grading of Recommendations Assessment, Development, and Evaluation system.We identified 13 randomized controlled trials .When using conventional meta_analysis of nine low risk of bias trials, we found a statistically significantly longer duration of analgesia,. |
