Context: The cytokine profiles of the bronchial mucosa in allergic and intrinsic asthma are distinctly different. Interleukins form a large group of cell signaling molecules within the cytokine family. IL-35 is a anti-inflammatory/immunosuppressive cytokine that inhibits important Th2-mediated inflammation in allergic asthma. (Huang et al, 2011). Aim: to measure IL35 serum level in asthmatic patients, and explore its significance and its correlation with the severity of asthma. Patients and Methods: the present study was conducted on 60 patients diagnosed with asthma and divided into 3 groups according to the guidelines of the Global Initiative for Asthma 2016 (GINA, 2016). They were classified into 3 groups; Group (1): case group included 20 patients of mild asthma, Group (2): case group included 20 patient of moderate asthma and Group (3): case group include 20 patient of severe asthma .A control group of 20 healthy volunteers apparently healthy non-atopic, age- and sex-matched, without personal or family history of asthma or other allergic conditions were included. Statistical analysis used: Statistical package of social sciences (Chicago, ILL Company) was used. Results: The results of this study revealed that Serum IL35 (ng/ml) showed significantly positive correlation with FEV1/FVC, significant negative correlations with Esinophil count and IgE in all studied cases. Otherwise, no significant correlations were found between serum Il35 with other studied parameters in all studied cases and control groups.
Conclusions: The results of this study revealed that Serum IL35 (ng/ml) showed significantly positive correlation with FEV1/FVC