Among patients with LC accompanied by bacterial infections, spontaneous bacterial peritonitis (SBP) is the most common complication (10% to 30% cases) and often life-threatening, with mortality among ranging from 10% to 46% (Dever JB and Sheikh MY, 2015).
The gold standard method for the diagnosis of SBP is a polymorphonuclear cell (PMN) count of ≥250 cells/mm3 in the ascitic fluid, regardless of bacterial isolation (Solà E, et al ,2016). However, paracentesis is not always possible and can sometimes be too time-consuming for an early diagnosis of SBP (Gaya DR, et al.2007).
Therefore, novel and useful biomarkers for early diagnosis of SBP are desirable. Laboratory methods for early prediction of response to the first treatment are also desirable because nonresponse to the first treatment is a predictor of mortality accompanied with SBP (Piano S, et al. 2016).
Studies have supported the view that CRP levels increases in decompensated cirrhosis and infections in cirrhosis. (Cervoni JP,et al.2012)
The aim of this study is to is clarify the role of high sensitive CRP as a prognostic factor in patient with spontaneous bacterial peritonitis
Patients :
This prospective study was conducted on 30 cases of cirrhosis with ascites who satisfied the criteria of SBP (elevated ascitic fluid absolute Polymorph Nuclear (PMN) leukocyte count of ≥250 cells/mm , in absence of any intra abdominal source of infection) & on a control group of 20 cirrhotic patient with ascitis & without SBP.
Methods
Highly sensitive CRP levels will be estimated after diagnosis of SBP and on 5th day after treatment with standard recommended antibiotic therapy (inj. cefotaxim 2 g 12 hourly for 5th days).
Results
There was no significant differences between both groups as regard age and gender with P values 0.071 & 0.103 respectively.
There was no significant differences between both groups as regard hemoglobin, total leucocyte count with P values 0.071, 0.463 respectively.
Mean creatinine level was significantly higher in cases (3.15) compared to controls (1.19). P value was |
