Background: Endometrial carcinoma is the commonest gynecological cancer in developed countries and second most common in developing countries. Endometrial hyperplasia can progress into endometrioid endometrial adenocarcinoma specially in the presence of cytological atypia and architectural crowding. Aim: This study aimed to assess the role of emmprin /CD147 expression in endometrial hyperplasia and endometrioid adenocarcinoma and to evaluate the potential risk of patients to develop cancer endometrium using nuclear morphometry. Methods: For immunohistochemical study, anti-Emmprin/CD147 staining was performed for each slide of endometrial hyperplasia and endometrioid adenocarcinoma using Avidin-Biotin complex technique and examined to assess their expression. Nuclear morphometric analysis was carried out by means of Olympus soft imaging system to measure the mean nuclear area (MNA) and the mean nuclear minimum (Mmnd) and maximum diameters (MMND). Results: The expression level of emmprin/CD147 was increased in the endometrioid adenocarcinoma cases compared with the cases of endometrial hyperplasia. It was also significantly increased (P |
