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Assist. Esraa Magdy Ahmed Seliem :: Publications:

Linseed oil supplementation improves altered lipid metabolism and insulin resistance in induced obese rats
Authors: Esraa M Seliem;Mohamed E Azab;Randa S Ismail;Abeer A Nafeaa
Year: 2022
Keywords: Linseed oil; Obesity; Insulin resistance; RBP4; GLUT4
Journal: Benha Veterinary Medical Journal
Volume: 41
Issue: 2
Pages: 73-78
Publisher: Esraa M Seliem
Local/International: Local
Paper Link:
Full paper Esraa Magdy Ahmed Seliem_BVMJ_Volume 41_Issue 2_Pages 73-78.pdf
Supplementary materials Not Available

The present work was performed to elucidate the effect of linseed oil supplementation on metabolic disorders in induced obese male albino rats. Thirty male Albino Wister rats were used in this investigation. They were categorized into two groups. 10 rats received a control diet and 20 rats were supplied a high-fat diet for 2 months till the induction of obesity. Then, rats were split into 3 groups (10 rats each). Group I, rats maintained on a control diet. Group II rats were maintained on HFD only. group III received HFD with 30% linseed oil supplementation for further two months. At the end of the experiment, the rats' body and organs weights were assessed. Blood samples and adipose tissue were obtained for analysis. The results revealed that linseed oil supplementation caused a substantial (P < 0.05) reduction in serum TC, TAG, LDL-C, VLDL-C, glucose, insulin levels, and HOMA-IR. However, HDL-C and adiponectin levels showed a significant (P < 0.05) increase when compared with the HFD group. Linseed oil supplementation also caused significant downregulation of retinol-binding protein 4 (RBP4) gene expression, however, the GLUT4 gene showed significant upregulation. From the obtained results it could be concluded that linseed oil has an ameliorative effect on altered lipid profile caused by obesity. In addition, linseed oil caused improvement in insulin resistance in addition to the pro and anti-inflammatory biomarkers.

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