Background: Prolonged ventilatory support is associated with poor clinical outcomes. Pressure support ventilation modes , are frequently used in clinical practice but are associated with patient–ventilator asynchrony and deliver fixed levels of assist. Neurally adjusted ventilatory assist (NAVA), a mode of partial ventilatory assist that reduces patient–ventilator asynchrony compared with other partial support modes for patients with difficult weaning. Objectives: To conduct a meta-analysis comparing neurally adjusted ventilatory assist (NAVA) with pressure support ventilation (PSV), in adult ventilated patients & clinical outcomes. Study design: Meta-analysis was used to address this concern. Sittings: Meta-analysis-based study following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guidelines. Methods: Online databases (PubMed, Embase, BioMed, and the Cochrane Central Register of Controlled trials)- were used for randomized studies ever performed in humans with NAVA & PSV in any clinical setting. Results: Twelve studies (n = 799 patients) were included. Regarding the primary outcome, patients weaned with NAVA had a higher success rate compared with pressure support ventilation. For the secondary outcomes, NAVA may reduce duration of mechanical ventilation and hospital mortality and prolongs ventilator-free days when compared with other modes. Conclusion: Our study suggests that the (NAVA) mode may improve the rate of weaning success compared with pressure support ventilation for difficult weaning |
