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Dr. Mahmoud Sayed Ahmed Khalaf Sayed :: Publications:

Title:
Memory-based model of drug release from Metformin Hydrochloride/Vildagliptin tablets
Authors: M. Khalaf; A. Elsaid; S. F. Hammad; W. K. Zahra
Year: 2024
Keywords: Not Available
Journal: AIP Conference Proceedings
Volume: 3094
Issue: 1
Pages: 500039
Publisher: AIP Publishing
Local/International: International
Paper Link:
Full paper Not Available
Supplementary materials Not Available
Abstract:

Memory effects are needed to be described in the diffusion process modelling since there is inconsistent rate with the classical approach. In this paper, a mathematical model is presented for simulation drug release from Metformin Hydrochlo-ride/Vildagliptin tablets based on fractional derivative (FD) and memory-dependent derivative (MDD). Our problem is represented by a set of two numerically solved diffusion equations. For both the tablet and the release medium, the profiles of drug concentration and mass are given and compared to the in vivo profiles. Results indicate that the FD and MDD are better suited for temporal modelling.

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