In this paper, a new Schif base was synthesized via the condensation reaction between 3-methyl-4-amino-5-mercapto-1,2,4
triazole and 2-hydroxy-1-naphthaldehyde. Also, the Cu(II) and Ag(I) complexes were synthesized. Besides, the CuO and
Ag nanoparticles were synthesized via thermal decomposition of Cu(II) and Ag(I) complexes at 800 °C. The products were
characterized using various techniques such as FT-IR, 1
HNMR, elemental microanalysis, UV–Vis spectrophotometer, mass
spectrophotometry, magnetic susceptibility measurements, molar conductance measurements, ESR, thermal analysis (TGA
and DSC), XRD, FE-SEM, and HR-TEM. The average crystallite size of CuO and Ag nanoparticles is 55.61 and 52.07 nm,
respectively. The direct band gap of the CuO and Ag samples is 2.95 and 3.20 eV, respectively. The synthesized nanopar-
ticles were utilized as photocatalysts for the degradation of methylene blue dye in aqueous media. The % degradation of
methylene blue dye (MB) is 94.25% within 20 min and 90.42% within 210 min in case of utilizing (CuO+ H2O2+UV) and
(Ag+ H2O2+UV), respectively. The products were tested for studying their antimicrobial activities against some bacterial
and fungal strains. The synthesized complexes and their nanoparticles show moderate activity against Escherichia coli and
Staphylococcus aureus bacterial strains. All the products showed no activity against Aspergillus favus and Candida albicans
fungal strains. Also, the synthesized compounds were screened for studying their cytotoxic activity against the human breast
cancer cell line (MCF-7). The results revealed that the Cu(II) complex could be nominated as a potential anticancer agent
because it showed a cytotoxic activity (IC50=7.33±0.6 μg/mL) nearly equal to that of cisplatin drug (IC50=5.71 μg/mL). |