| Abstract |
Our experimental goal was to assess the protective effects of allicin (AC) and omega3
(OMG-3 FAs) against paracetamol (APAP) induced hepato-renal injury in rats. Seventy Wistar albino
rats were assigned to 7 experimental groups, each was composed of 10 rats; 1st group received saline
only (Control), 2nd group supplemented with allicin (AC) (10 mg/kg. b. wt. orally), 3rd group
supplemented with omega-3 (OMG-3 FAs) (100 mg/kg b. wt. orally), 4th group paracetamol (APAP)
toxic control group received saline orally once daily and a single 1 g/kg orally dose of APAP on the 27th
day of the experiment. 5th group (AC + APAP), 6th group (OMG-3 + APAP), and 7th group
(AC+ OMG-3+ APAP). rats in these groups have been received allicin, omega-3, and/or APAP as
described above. Saline, allicin, and omega-3 were administered for 30 days. Paracetamol showed a
significant increase in ALT, AST, ALP, urea, creatinine and MDA and a significant decrease in SOD,
CAT and GSH levels. Also, The APAP intoxicated group showed a significant decrease in albumin and
total protein and a marked increase in cholesterol and triglycerides when compared to the control group.
Hematological parameters also investigated and indicated in result. Histopathological changes were also
recorded and indicated in the results. Caspase-3 and HSP70 were substantially unregulated by APAP in
the renal and hepatic tissues. Concurrent supplementation of AC and/or OMG-3 FAs with APAP resulted
in a notable improvement in estimated parameters compared to the APAP group. Therefore, we
anticipate that prescribing omega3 and allicin in patients undergo paracetamol regimen would be
beneficial in reducing the adverse effect of paracetamol-induced hepatic and renal damage. |
