Background: A complex autoimmune disease, systemic lupus erythematosus (SLE) mostly strikes females. The abnormal accumulation of immune complexes, the involvement of numerous organs, and the excessive production of different types of autoantibodies are the hallmarks of this condition. the purpose of this study cognitive function disorders in adult patients with lupus nephritis (LN) and their correlation with the disease activity of LN, as compared to SLE without nephritis. Methods: This case-controlled study included 120 patients who carried out at the Nephrology Unit, Internal Medicine Department, at Benha University Hospitals from April 2022 to April 2024. Patients were divided into two groups: Group 1: Fifty adult patients with SLE who fulfill the criteria of American College of Rheumatology, Group 2: Seventy adult patients with LN. Results: The estimated glomerular filtration rate, complement component 3, and complement component 4 in the LN group all showed significant positive correlations with the Montreal Cognitive Assessment (MOCA )score. Otherwise, the following markers were found to be significantly inversely correlated with the MOCA score: systolic and diastolic blood pressure, urea and creatinine levels, total leukocyte count, erythrocyte sedimentation rate, C-reactive protein, antiphospholipid antibodies, lupus anticoagulant, protein/creatinine ratio, albumin/creatinine ratio, 24-hour urine protein, activity index, and chronicity index |
