The current study aimed to investigate the effects of combined toxicity of Fipronil insecticide and Potassium- dichromate on liver of albino rats. The rats were randomly assigned into 5 equal groups (10 rats each). Group 1: controls received daily Filtered water orally. Group 2: control received day after day corn oil orally. Group 3: received FPN day after day at a dose of 10 mg/kg b. wt. orally. Group 4: received K2Cr2O7 daily via drinking water (700 ppm equivalent to 67 mg/kg b.wt) .Group 5: received FPN day after day (10 mg/kg b. wt orally) + K2Cr2O7 daily via drinking water (700 ppm equivalent to 67 mg/kg b.wt) for 28days. The results revealed that FPN and/or K2Cr2O7significantly increased serum levels of ALT, AST and decrease in total protein and albumin. In addition, there were substantial increases in the liver contents of MDA and NO, along with significant decreases in TAC. also, there is upregulation in TNF-α and IL-6. It can be concluded that FPN and/or K2Cr2O7 induce severe tissue damage in liver of male albino rats. |
